RETRACTED: γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo
نویسندگان
چکیده
Laura E. Doglio, Ritu Kanwar, George R. Jackson, Mar Perez, Jesús Avila, Colin Dingwall, Carlos G. Dotti, Mark E. Fortini,* and Fabián Feiguin* Cavalieri Ottolenghi Scientific Institute Universita degli Studi di Torino 10043, Orbassano, Torino Italy Department of Human Genetics Catholic University of Leuven and Flanders Interuniversity Institute of Biotechnology (VIB) 3000 Leuven Belgium Center for Cancer Research National Cancer Institute Frederick, Maryland 21702 Neurogenetics Program Department of Neurology David Geffen School of Medicine at the University of California, Los Angeles Los Angeles, California 90095 Centro de Biologia Molecular ‘‘Severo Ochoa’’ Universidad Autonoma de Madrid 28049 Madrid Spain Neurology and GI CEDD GlaxoSmithKline Pharmaceuticals Harlow, Essex CM195AW England
منابع مشابه
γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo
Genetic analysis of familial Alzheimer's disease has revealed that mutations in the gamma-secretase enzyme presenilin promote toxic Abeta secretion; however, presenilin mutations might also influence tau hyperphosphorylation and neurodegeneration through gamma-secretase-independent mechanisms. To address this possibility and determine whether other components of the gamma-secretase complex poss...
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γ-Secretase, a multisubunit transmembrane protease comprised of presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective one, participates in the regulated intramembrane proteolysis of Type I membrane proteins including the amyloid precursor protein (APP). Although Aph-1 is thought to play a structural role in the assembly of γ-secretase complex and several transmembrane dom...
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عنوان ژورنال:
- Neuron
دوره 50 شماره
صفحات -
تاریخ انتشار 2006