Further Studies on the Role of Metabolites in MDMA-induced Serotonergic Neurotoxicity
نویسندگان
چکیده
Department of Neurology (MM, JY, GR) and Psychiatry and Behavioral Sciences (UM), Johns Hopkins University School of Medicine, Baltimore, MD 21224; UMR 8638 associée au CNRS (AF, AN, ML), Université Paris Descartes, 75270 Paris cedex 06, France; Department of Experimental and Clinical Toxicology (MM, FP, HM), Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D-66421 Homburg (Saar), Germany DMD Fast Forward. Published on July 23, 2009 as doi:10.1124/dmd.109.028340
منابع مشابه
Further studies on the role of metabolites in (+/-)-3,4-methylenedioxymethamphetamine-induced serotonergic neurotoxicity.
The mechanism by which the recreational drug (+/-)-3,4-methylenedioxymethamphetamine (MDMA) destroys brain serotonin (5-HT) axon terminals is not understood. Recent studies have implicated MDMA metabolites, but their precise role remains unclear. To further evaluate the relative importance of metabolites versus the parent compound in neurotoxicity, we explored the relationship between pharmacok...
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