Hemichromes in single inclusion bodies in red cells of beta thalassemia.

Inclusion bodies in the red cells of pahemichrome. In the present study, mitients with thalassemia syndromes may crospectrophotometric examination of result from precipitation of those single inclusion bodies in ghosts prehemoglobin subunits that are produced pared from the red cells of two patients in relative excess. In hemoglobin H diwith fl-thalassemia major revealed the sease, a form of a-thalassemia, the inabsorption spectrum of hemichrome. clusions are precipitated fl-subunits, These results suggest that hemiwhile in the fi-thalassemias they are achrome formation is an important subunits. It has been shown that the pathogenetic event in the production of inclusions in hemoglobin H disease red cell inclusions and consequent have the spectral characteristics of hemolysis in the thalassemias.