Regioselective and Diastereoselective Aminoarylation of 1,3-Dienes.

نویسندگان

  • Hongli Bao
  • Liela Bayeh
  • Uttam K Tambar
چکیده

The 1,4-functionalization of dienes is a synthetically useful strategy for incorporating molecular complexity into a class of simple substrates. We report the aminoarylation of acyclic and cyclic 1,3-dienes via the sequential [4+2] cycloaddition with a sulfurdiimide reagent and copper-catalyzed allylic substitution with Grignard reagents. The regioselective and diastereoselective aminoarylation of unsymmetrical dienes is also presented, which highlights the utility of this method for generating products with multiple functional groups and stereocenters.

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عنوان ژورنال:
  • Chemical science

دوره 5 12  شماره 

صفحات  -

تاریخ انتشار 2014