Great Expectations: MicroRNA-30d and Cardiac Resynchronization Therapy Running title: Dorn; miR-30d as a biomarker for resynchronization success
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Great Expectations: MicroRNA-30d and Cardiac Resynchronization Therapy.
The broken heart. You think you will die, but you just keep living, day after day after terrible day. 1 T here seem to be as many approaches to managing heart failure as there are causal factors. Heart failure management is evolving from a one-size-fits-all approach centered around therapy with neurohormonal antagonists toward strategies tailored to provide the optimal clinical benefit based on...
متن کاملResponse to Letter Regarding Article, "Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study".
We thank Sardu and colleagues for their comments. Our report demonstrates that baseline levels of microRNA-30d (miR-30d) are correlated with response to cardiac resynchronization therapy and that miR-30d was dynamically regulated by mechanical stress. Moreover, miR-30d appeared to be an adaptive response and was cardioprotective against tumor necrosis factor-α–mediated apoptosis. Similar to our...
متن کاملCirculating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study.
BACKGROUND Biomarkers that predict response to cardiac resynchronization therapy (CRT) in heart failure patients with dyssynchrony (HFDYS) would be clinically important. Circulating extracellular microRNAs (miRNAs) have emerged as novel biomarkers that may also play important functional roles, but their relevance as markers for CRT response has not been examined. METHODS AND RESULTS Comprehen...
متن کاملCirculating miR-30d Predicts Survival in Patients with Acute Heart Failure.
BACKGROUND/AIMS Identification of novel biomarkers to identify acute heart failure (AHF) patients at high risk of mortality is an area of unmet clinical need. Recently, we reported that the baseline level of circulating miR-30d was associated with left ventricular remodeling in response to cardiac resynchronization therapy in advanced chronic heart failure patients. However, the role of circula...
متن کاملUrinary MicroRNA-10a and MicroRNA-30d Serve as Novel, Sensitive and Specific Biomarkers for Kidney Injury
The steadily increasing incidence of kidney injury is a significant threat to human health. The current tools available for the early detection of kidney injury, however, have limited sensitivity or specificity. Thus, the development of novel biomarkers to detect early kidney injury is of high importance. Employing mouse renal ischemia-reperfusion and streptozotocin (STZ)-induced renal injury a...
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