Serological evidence of human klassevirus infection.

نویسندگان

  • Alexander L Greninger
  • Lori Holtz
  • Gagandeep Kang
  • Donald Ganem
  • David Wang
  • Joseph L DeRisi
چکیده

Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological enzyme-linked immunosorbent assay (ELISA). Four of six klassevirus reverse transcription (RT)-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 17 10  شماره 

صفحات  -

تاریخ انتشار 2010