TRANSLATIONAL PHYSIOLOGY Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma
نویسندگان
چکیده
Elizabeth S. Klings, Surinder Safaya, Adeboye H. Adewoye, Adam Odhiambo, Garrett Frampton, Marc Lenburg, Norman Gerry, Paola Sebastiani, Martin H. Steinberg, and Harrison W. Farber The Pulmonary Center, Division of Hematology/Oncology, Department of Medicine, Department of Genetics/Genomics, Boston University School of Medicine, and Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts
منابع مشابه
Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma.
Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that endothelial cell (EC) dysfunction, one possible modifier of disease variability, results from induction of phenotypic changes by circulating factors. Accordingly, we analyzed gene expression in cultured human pulmonary artery ECs (HPAEC) exp...
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