Elevated Intraocular Pressure Induces Amyloid-b Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma
نویسندگان
چکیده
Zhichao Yan, Huanquan Liao, Hongrui Chen, Shuifeng Deng, Yu Jia, Caibin Deng, Jianxian Lin, Jian Ge, and Yehong Zhuo State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People’s Republic of China Department of Ophthalmology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China Department of Neurology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People’s Republic of China Department of Ophthalmology, The Third People’s Hospital of Huizhou, Huizhou, People’s Republic of China
منابع مشابه
Elevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma.
Purpose Recent evidence has suggested a potential association between Alzheimer's disease (AD) and glaucoma and found significant deposition of amyloid-β (Aβ) and Tau protein in the retinas of glaucoma patients. However, no coherent finding has emerged regarding the AD-like changes in the central visual system (CVS). Studies confirming the presence of Aβ and Tau neuropathology are warranted to ...
متن کاملExperimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus.
PURPOSE To examine the effects that elevated intraocular pressure (IOP), a glaucoma risk factor, has on the size, density, and number of neurons in the primate lateral geniculate nucleus (LGN). METHODS The monkey model of experimental glaucoma was combined with standard histologic staining and analysis techniques. Fourteen animals were examined. RESULTS Mean IOPs higher than 40 mm Hg for 2....
متن کاملSelective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus.
Rapid-phase axonal transport to the dorsal lateral geniculate nucleus (dLGN) was determined autoradiographically in seven macaque monkey eyes with chronic intraocular pressure (IOP) elevation, in four eyes with an acute IOP elevation, and in three eyes with normal IOP. The monkeys with chronic IOP elevation showed a greater decrease in radioactive labeling of the magnocellular layers of the dLG...
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The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
متن کاملMagnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma.
PURPOSE Neurochemical changes in nerve cells were investigated in the lateral geniculate nucleus (LGN) and primary visual cortex of macaque monkeys with experimentally induced glaucoma. METHODS Glaucomatous damage was induced in one eye of experimental animals by elevation of intraocular pressure following laser burns to the trabecular meshwork. Staining for the metabolic marker cytochrome ox...
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