Erratum to: Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case–control study

نویسندگان

  • Benjamin A. Fisher
  • Alison J. Cartwright
  • Anne-Marie Quirke
  • Paola de Pablo
  • Dora Romaguera
  • Salvatore Panico
  • Amalia Mattiello
  • Diana Gavrila
  • Carmen Navarro
  • Carlotta Sacerdote
  • Paolo Vineis
  • Rosario Tumino
  • David F. Lappin
  • Danae Apatzidou
  • Shauna Culshaw
  • Jan Potempa
  • Dominique S. Michaud
  • Elio Riboli
  • Patrick J. Venables
چکیده

Author details Rheumatology Research Group, Centre for Translational Inflammation Research, Queen Elizabeth Hospital Birmingham, Birmingham B15 2WB, UK. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. School of Public Health, Imperial College London, London, UK. CIBER-OBN (Fisiopatología de la Obesidad y Nutrición), Madrid, Spain. Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy. Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Murcia, Spain. Human Genetics Foundation, Turin, Italy. Cancer Registry and Histopathology Unit, “Civic M.P.Arezzo” Hospital, ASP Ragusa, Ragusa, Italy. University of Glasgow Dental School, University of Glasgow, Glasgow, UK. Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. Oral Health and Systemic Research Group, School of Dentistry, University of Louisville, Louisville, USA. Department of Epidemiology, Brown University School of Public Health, Providence, USA.

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Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case–control study

BACKGROUND Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We aimed to study the relation of these factors to the risk of RA in a prospective cohort. METHODS...

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The Relationship between Porphyromonas gingivalis and Rheumatoid Arthritis: a Cross-Sectional Clinical, Microbiological, and Molecular Approach

Background: The relationship between rheumatoid arthritis and poor oral hygiene has longbeen proven. Colonization of Porphyromonas gingivalis in the oral cavity can play an important role in rheumatoid arthritis. The aim of this study was to determine whether there is a relationship between rheumatoid arthritis disease and the presence of P. gingivalis. <stro...

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The Infectious Basis of ACPA-Positive Rheumatoid Arthritis

Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers in RA, namely Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans causes of periodontal disease (PD), and Epstein...

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Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and epidemiologically. Recent findings suggest a causative link between periodontal infection and rheumatoid arthritis via bacteria-dependent induction of a pathogenic autoimmune response to citrullinated epitopes. Here we showed that infection with...

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عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2016