Structure-Based Design, Synthesis and Testing of Non-Peptide, Cell-Permeable, Potent Small Molecule Smac Mimetics as a New Therapy for Prostate Cancer PRINCIPAL INVESTIGATOR:
نویسنده
چکیده
منابع مشابه
Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells
Cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2) and X-linked inhibitor of apoptosis protein (XIAP) are key apoptosis regulators and promising new cancer therapeutic targets. This study describes a set of non-peptide, small-molecule Smac (second mitochondria-derived activator of caspases) mimetics that are selective inhibitors of cIAP1/2 over XIAP. The most potent and most selective co...
متن کاملDesign and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents
Cancer disease is a great concern in the worldwide public health and current treatments do not give satisfactory results, so, developing novel therapeutic agents to combat cancer is highly demanded. Nowadays, anticancer peptides (ACPs) are becoming promising anticancer drug candidates. This is due to several advantages inherited in peptide molecules, such as being usually with small size, high ...
متن کاملDesign and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents
Cancer disease is a great concern in the worldwide public health and current treatments do not give satisfactory results, so, developing novel therapeutic agents to combat cancer is highly demanded. Nowadays, anticancer peptides (ACPs) are becoming promising anticancer drug candidates. This is due to several advantages inherited in peptide molecules, such as being usually with small size, high ...
متن کاملDesign and Development of Peptides from the Anti-Angiogenic Pigment Epithelial-Derived Factor for the Therapy of Prostate Cancer PRINCIPAL INVESTIGATOR:
Mirochnik Y, Filleur S, Volpert O. Pigment Epithelial derived factor: development of anti-angiogenic peptides. 2006. European J Cancer 4S (12):37 Presentation: Symposium on “Molecular Targets and Cancer Therapeutics”. Prague, Czech Republic 7-10 November 2006 Abstract: Mirochnik Y, Aurora A., Volpert O. Pigment epithelial derived factor: design and development of anti-angiogenic peptides for th...
متن کاملRegulation of cancer stem-like cell differentiation by Smac mimetics
Small-molecule antagonists of inhibitor of apoptosis (IAP) proteins such as Smac mimetics are considered promising cancer therapeutics through the engagement of cell death pathways. Recent evidence suggests that Smac mimetics perform additional nonapoptotic functions by initiating differentiation in cancer stem-like cells, opening new perspectives for their future clinical application.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006