Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 -subunit in rats with cystitis
نویسندگان
چکیده
Yukio Hayashi, Koichi Takimoto, Michael B. Chancellor, Kristin A. Erickson, Vickie L. Erickson, Tsukasa Kirimoto, Koushi Nakano, William C. de Groat, and Naoki Yoshimura Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh; Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh; Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Taiho Pharmaceutical, Tokushima, Japan
منابع مشابه
Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis.
Hyperexcitability of C-fiber bladder afferent pathways has been proposed to contribute to urinary frequency and bladder pain in chronic bladder inflammation including interstitial cystitis. However, the detailed mechanisms inducing afferent hyperexcitability after bladder inflammation are not fully understood. Thus, we investigated changes in the properties of bladder afferent neurons in rats w...
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The properties of bladder afferent neurons in L6 and S1 dorsal root ganglia of adult rats were evaluated after chronic bladder inflammation induced by 2 week treatment with cyclophosphamide (CYP; 75 mg/kg). Whole-cell patch-clamp recordings revealed that most (70%) of the dissociated bladder afferent neurons from control rats were capsaicin sensitive, with high-threshold long-duration action po...
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Objective(s):We investigated the relationship between the expression of tumor necrosis factor-inducible gene 6 (TSG-6) with inflammation and integrity of the bladder epithelium in the bladder tissues of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and the mechanism of action using a rat model of BPS/IC. Materials and Methods: Expression of TSG-6 and uroplakin III was det...
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Vizzard, Margaret A. Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis. Am J Physiol Regulatory Integrative Comp Physiol 278: R1027–R1039, 2000.—These studies examined Fos protein expression in spinal cord neurons synaptically activated by stimulation of bladder afferent pathways after cyclophosphamide (CYP)-induced bladder inflammation. In uret...
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