Impact of Dual-Chamber Permanent Pacing in Patients With Obstructive Hypertrophic Cardiomyopathy With Symptoms Refractory to Verapamil and j3-Adrenergic Blocker Therapy
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چکیده
Background. Patients with obstructive hypertrophic cardiomyopathy (HCM) with symptoms refractory to drugs (j3-blockers or verapamil) are candidates for cardiac surgery (left ventricular septal myectomy or mitral valve replacement). The present study examines prospectively the ability of dual-chamber (DDD) pacing to improve symptoms and relieve left ventricular outflow obstruction in such patients. Methods and Results. Forty-four consecutive patients with obstructive HCM who had failed to benefit from pharmacotherapy underwent treadmill exercise tests, echocardiography, and cardiac catheterization before and 1.5-3 months after implantation of a DDD pacemaker. Symptoms (angina, dyspnea, palpitations, presyncope, and syncope), New York Heart Association functional class status (1.7±0.7
منابع مشابه
Impact of dual-chamber permanent pacing in patients with obstructive hypertrophic cardiomyopathy with symptoms refractory to verapamil and beta-adrenergic blocker therapy.
BACKGROUND Patients with obstructive hypertrophic cardiomyopathy (HCM) with symptoms refractory to drugs (beta-blockers or verapamil) are candidates for cardiac surgery (left ventricular septal myectomy or mitral valve replacement). The present study examines prospectively the ability of dual-chamber (DDD) pacing to improve symptoms and relieve left ventricular outflow obstruction in such patie...
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متن کاملSymptomatic Patients With Obstructive Hypertrophic Cardiomyopathy: A Randomized, Assessment of Permanent Dual-Chamber Pacing as a Treatment for Drug-Refractory
Barry J. Maron, Rick A. Nishimura, William J. McKenna, Harry Rakowski, Mark E. Josephson Double-Blind, Crossover Study (M-PATHY) Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy: A Randomized, Assessment of Permanent Dual-Chamber Pacing as a Treatment for Drug-Refractory Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1999 American Heart Association, Inc. All rights r...
متن کاملAssessment of permanent dual-chamber pacing as a treatment for drug-refractory symptomatic patients with obstructive hypertrophic cardiomyopathy. A randomized, double-blind, crossover study (M-PATHY).
BACKGROUND Dual-chamber pacing (DDD) has been proposed as a treatment alternative to surgery for severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), based largely on uncontrolled studies. METHODS AND RESULTS This prospective, multicenter trial assessed pacing in 48 symptomatic HCM patients with >/=50 mm Hg basal gradient, refractory to drug therapy. Patients were...
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