Porphyromonas gingivalis Resistance of C4b-Binding Protein Contributes to Serum Binding of Complement Inhibitor
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Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis.
The periodontal pathogen Porphyromonas gingivalis is highly resistant to the bactericidal activity of human complement, which is present in the gingival crevicular fluid at 70% of serum concentration. All thirteen clinical and laboratory P. gingivalis strains tested were able to capture the human complement inhibitor C4b-binding protein (C4BP), which may contribute to their serum resistance. Ac...
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