PROactive in patients with type 2 diabetes and previous myocardial infarction: swinging the sword of Damocles?
نویسنده
چکیده
ype 2 diabetes increases the risk of coronary heart disease t least by 2to 3-fold. Patients with type 2 diabetes without history of myocardial infarction (MI) have the same risk or fatal MI as nondiabetic subjects with a history of MI 1,2). Moreover, type 2 diabetic patients with previous MI re even more susceptible to coronary events and need all vailable evidence-based tools for cardiovascular risk reducion. Thiazolidinediones or glitazones are selective ligands f peroxisome-proliferator-activated receptor (PPAR)amma addressing insulin resistance, a culprit of the metaolic syndrome and type 2 diabetes (3). Currently, 2 idely used compounds of thiazolidinediones, pioglitazone nd rosiglitazone, have been approved for the treatment of yperglycemia in type 2 diabetes. Because of their effect on
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عنوان ژورنال:
- Journal of the American College of Cardiology
دوره 49 17 شماره
صفحات -
تاریخ انتشار 2007