White matter lesion intensity and cognitive ability: relationships in youth and old age
نویسندگان
چکیده
M. Valdés Hernandez, L. Penke, S. Muñoz Maniega, C. Murray, N. Royle, A. J. Gow, J. M. Starr, M. E. Bastin, I. J. Deary, and J. M. Wardlaw Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom, Psychology, University of Edinburgh, Edinburgh, United Kingdom, Geriatric Medicine, University of Edinburgh, Edinburgh, United Kingdom, Medical Physics, University of Edinburgh, Edinburgh, United Kingdom
منابع مشابه
Estimated maximal and current brain volume predict cognitive ability in old age
Brain tissue deterioration is a significant contributor to lower cognitive ability in later life; however, few studies have appropriate data to establish how much influence prior brain volume and prior cognitive performance have on this association. We investigated the associations between structural brain imaging biomarkers, including an estimate of maximal brain volume, and detailed measures ...
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Cerebral white matter hyperintensities (WMH) reflect accumulating white matter damage with aging and impair cognition. The role of childhood intelligence is rarely considered in associations between cognitive impairment and WMH. We studied community-dwelling older people all born in 1936, in whom IQ had been assessed at age 11 years. We assessed medical histories, current cognitive ability and ...
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OBJECTIVE To test the hypothesis that white matter integrity, as measured by diffusion tensor and magnetization transfer MRI is significantly associated with cognitive ability measured in youth and old age. METHODS Forty, nondemented, surviving participants of the Scottish Mental Survey of 1932 underwent brain MRI and a battery of psychometric tests covering major cognitive domains and tests ...
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BACKGROUND AND PURPOSE Cerebral white matter lesions and lacunar infarcts are small vessel disease-related lesions, which are associated with cognitive decline and dementia. We aimed to assess the relationship between risk factors, effect modifiers, and progression of these lesions. Furthermore, we studied the cognitive consequences of lesion progression. METHODS Six hundred sixty-eight peopl...
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Cerebral white matter abnormalities relate to cognitive functioning in elders. We examine whether this association is (a) independent of mental ability in youth and (b) related to general and/or specific mental abilities. We retested 83 participants of the Scottish Mental Survey of 1932 on a battery of mental tests. Their brains were scanned by magnetic resonance imaging. Three independent rati...
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