Label-Free Optical Detection of Fibrinogen in Visible Region Using Nanoimprint Lithography-Based Two-Dimensional Photonic Crystal

For the future medical diagnostics, high-sensitive, rapid, and cost effective biosensors to detect the biomarkers have been desired. In this study, the polymer-based two-dimensional photonic crystal (2DPC) was fabricated using nanoimprint lithography (NIL) for biosensing application. In addition, for biosensing application, label-free detection of fibrinogen which is a biomarker to diagnose the chronic obstructive pulmonary disease (COPD) could be achieved using antigen-antibody reaction high-sensitively (detection limit: pg/ml order) and rapidly. Using this polymer-based 2D-PC, optical biosensor can be developed cost effectively. Furthermore, by using polymer as a base material for fabrication of 2DPC, label-free detection of antigen-antibody reaction can be performed in visible region. key words: photonic crystal, biosensor, polymer, nanoimprint lithography