Descending vasomotor pathways from the dorsomedial hypothalamic nucleus: role of medullary raphe and RVLM.

Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus.

Physiological and anatomic methods were used to determine whether neurons in the rostral ventrolateral medulla (RVLM), nucleus tractus solitarius (NTS), or hypothalamic paraventricular nucleus (PVN) mediate the cardiovascular response evoked from the dorsomedial hypothalamic nucleus (DMH), which is believed to play a key role in mediating responses to stress. In urethane-anesthetized rats, acti...

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow.

Despite considerable interest in the neural mechanisms that regulate muscle blood flow, the descending pathways that control sympathetic outflow to skeletal muscles are not adequately understood. The present study mapped these pathways through the transneuronal transport of two recombinant strains of pseudorabies virus (PRV) injected into the gastrocnemius muscles in the left and right hindlimb...

Effect of Specific Lesion of Non Serotonergic Pathway on Neurons of Nucleus Raphe Magnus Morphology in Rat

Purpose: The nucleus raphe magnus (NRM) is a medullary nucleus containing serotonergic and non serotonergic neurons, both of which densely project to spinal cord. The goal of this study was to determine the role of these non serotonergic neurons in pain perception and their cytological changes after the specific lesion of bulbo-spinal serotonergic pathway. Materials and Methods: Male rats were...

Expression of RFamide-Related Peptide-3 (RFRP-3) mRNA in Dorsomedial Hypothalamic Nucleus and KiSS-1 mRNA in Arcuate Nucleus of Rat during Pregnancy

Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways

Activation of the dorsomedial nucleus of the hypothalamus (DMH) by galanin (GAL) induces behavioural hyperalgesia. Since DMH neurones do not project directly to the spinal cord, we hypothesized that the medullary dorsal reticular nucleus (DRt), a pronociceptive region projecting to the spinal dorsal horn (SDH) and/or the serotoninergic raphe-spinal pathway acting on the spinal 5-HT3 receptor (5...