Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque.
نویسندگان
چکیده
The serum determination of gamma-glutamyltransferase ( -GT) activity is a low-cost, highly sensitive and accurate, and frequently used laboratory test. Although it is considered to be an index of hepatobiliary dysfunction and alcohol abuse,1 recent epidemiology and pathology studies have suggested its independent role in the pathogenesis and clinical evolution of cardiovascular diseases brought on by atherosclerosis.1,2
منابع مشابه
Triggering Oxidative Stress Within the Plaque
Copyright © 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/CIRCULATIONAHA.105.571919 2005;112;2078-2080 Circulation Michele Emdin, Alfonso Pompella and Aldo Paolicchi Triggering Oxidative Stress Within the Plaque Gamma-Glutamyltransferase, Athero...
متن کاملGamma-glutamyltransferase to determine cardiovascular risk: shifting the paradigm forward.
Gamma-glutamyltransferase (GGT), regarded as a marker of excessive alcohol consumption or liver disturbances, is an enzyme catalyzing the first step in the extracellular degradation of the antioxidant glutathione (GSH) and may take part in atherogenesis. The marked relationship between GGT and the atherosclerotic process has shifted attention to the issue of whether its serum levels can aid in ...
متن کاملThe Potential Roles of Gamma-Glutamyltransferase Activity in the Pro- gression of Atherosclerosis and Cardiovascular Diseases
The oxidation of low density lipoproteins (LDL) is regarded as a critical factor in the pathogenesis of atherosclerosis, especially the initial steps of the disease. In addition, other oxidative events have been shown to participate in the progression of atherosclerosis and precipitation of cardiovascular events, through modulation of important components of lesions of the vessel wall (smooth m...
متن کاملAssociation between serum gamma-glutamyltransferase activity and carotid intima-media thickness.
Serum gamma-glutamyltransferase (GGT) activity is a marker of oxidative stress and activity is associated with cardiovascular disease. Carotid intima-media thickness (IMT) is a noninvasive predictor of atherosclerosis. We investigated the association between serum GGT activity and carotid IMT. Fifty-five persons who had normal liver function tests were consecutively enrolled. Carotid IMT was ev...
متن کاملGamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk Citation
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation
دوره 112 14 شماره
صفحات -
تاریخ انتشار 2005