Recurrent miscarriage
نویسنده
چکیده
Miscarriage is one of the most common complications of pregnancy. Fifteen percent of clinically recognized pregnancies end in miscarriage. The major cause of spontaneous miscarriage is genetic or developmental abnormalities of the foetus. Recurrent miscarriage occurs in 3% of the population and has been associated with thrombophillias, infections and endocrine, anatomical and immune factors. Treatments to prevent miscarriage remain largely untested by randomized controlled trials (RCTs). The results of the limited available evidence indicate that the wide use of empirical treatments has led to minimal benefit for both patients and health care providers. This article is therefore designed to enhance critical thinking and improve clinical skills in an area with extensive and contradictory literature.
منابع مشابه
The Prevalence of Common Mutations in Thrombophilic Patients in Iranian Population with Recurrent Miscarriage
Background and Aims: To date, several factors have been reported in recurrent miscarriage. Genetic mutations are the most important causative factors in women. Fetal thrombotic vasculopathy is a new described placental alteration with varying degrees of involvement and often associated with adverse prenatal outcomes. The diagnosis is made histologically and so is postnatal, which makes it a cha...
متن کاملI-43: Investigation and Treatment of Coupleswith Recurrent Miscarriage in Royan
Recurrent abortion is classically defined as three or more consecutive pregnancy losses, although recently more than two pregnancy losses also considered as recurrent abortions. This condition affects approximately 1% of couples at reproductive age. Recurrent pregnancy loss has been attributed to anatomic uterine pathologies, genetic defects, endocrine disorders, immunologic factors, prothrombo...
متن کاملThe Effect of Vitamin E and Selenium on Sperm Chromatin Quality in Couples with Recurrent Miscarriage
Background and Aims: Due to the paucity of studies, association between the morphology and function of sperm and recurrent miscarriage (RM) is not yet completely known. Increased reactive oxygen species and decreased antioxidant levels in men have been shown to be associated with RM. Recently it has been accepted that antioxidant therapy can approve sperm parameters. The goal of this study was ...
متن کاملOnm-1: The Association of Apoprotien E Polymorphisms with Recurrent Miscarriage in Iranian Women
Background: Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the ApoE gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss. Mate...
متن کاملP-233: Study of Chromosomal Alterations and Polymorphisms of MTHFR, Factor V and Prothrombin Genes in Patients with Recurrent Miscarriage Referred to Royan Institute
Background: Recurrent miscarriage (RM) is defined as two or more consecutive pregnancy losses before 20 weeks of gestation as an important clinical problem, with an incidence of 1-3% among couples wishing to have children. There are several factors in the etiology of recurrent miscarriage. One of the main genetic causes which involve in the pathogenesis of RM is balanced chromosomal rearrangeme...
متن کاملClinical characteristics of pregnancies with a history of recurrent miscarriage at a Japanese perinatal center.
OBJECTIVE We examined obstetric and fetal/neonatal outcomes in women with a history of recurrent miscarriage. METHODS We reviewed the obstetric records of all 5,829 nulliparous pregnant women who delivered at #8805;14 weeks' gestation from 2008 through 2013 at our perinatal center. Of these women, 74 had a history of recurrent miscarriage (1.3%). The control population consisted of 4,176 null...
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