The Third-generation Bisphosphonates Inhibit Tumor Proliferation in Human Fibrosarcoma
نویسندگان
چکیده
+*Koto, K; *Murata, H; *Sakabe, T; *Matsui, T; *Horie, N; *** Kimura, S; ***Maekawa, T; **Fushiki, S; *Kubo, T + *Department of Orthopaedics, Graduate School of Medical Science. Kyoto Prefectural University of Medicine, Kyoto, Japan **Department of Pathology and Applied Neurobiology, Graduate School of Medical Science. Kyoto Prefectural University of Medicine, Kyoto, Japan ***Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan e-mail: [email protected]
منابع مشابه
Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents.
Third-generation bisphosphonates are known to inhibit bone resorption and also appear to exhibit direct anti-tumour activity. We previously reported that third-generation bisphosphonates such as zoledronic acid (ZOL) have a direct antitumour effect, and synergistically augment the effects of antitumor agents in osteosarcoma cells. There has been no report on the antitumor effect of ZOL against ...
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