Comments on the safety assessment of decamethylcyclopentasiloxane (D5) published in regulatory toxicology and pharmacology, 2017, 83:117-118.

Opinion of the Scientific Committee on Consumer Safety (SCCS) - Final version of the opinion on decamethylcyclopentasiloxane (cyclopentasiloxane, D5) in cosmetic products.

Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.

There are currently seven published physiologically based pharmacokinetic (PBPK) models describing aspects of the pharmacokinetics of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) for various exposure routes in rat and human. Each model addressed the biological and physico-chemical properties of D4 and D5 (highly lipophilic coupled with low blood: air partition coeffic...

Chronic toxicity and oncogenicity of decamethylcyclopentasiloxane in the Fischer 344 Rat.

Decamethylcyclopentasiloxane (D5) is a cyclic polydimethylsiloxane used in the synthesis of silicon-based materials and as a component in consumer products. Male and female Fischer 344 rats were exposed to D5 vapor (0, 10, 40, 160 ppm; whole-body inhalation) for 6 h/d, 5 d/wk, for up to 104 weeks. Microscopic examination of tissues revealed test article effects at 160 ppm in the upper respirato...

Characterization of ecological risks from environmental releases of decamethylcyclopentasiloxane (D5).

Decamethylcyclopentasiloxane (D5) is used in personal care products and industrial applications. The authors summarize the risks to the environment from D5 based on multiple lines of evidence and conclude that it presents negligible risk. Laboratory and field studies show that D5 is not toxic to aquatic organisms or benthic invertebrates up to its solubility limit in water or porewater or its s...

Describing the Role and Duties of a Military Pharmacist in Iran Armed Forces Health Care System

Background and Aim: Due to the comprehensiveness of educational topics and mastery of various scientific topics, including mathematics, physics, chemistry, and biology on the one hand, and management, business and economics on the other, pharmacists have a significant ability to perform various tasks in the healthcare system. In the meantime, pharmacists who are exposed to military training, as...