HLA epitopes and tolerance induction protocols.

R. A. Montgomery addresses in a recent editorial ‘‘One Kidney for Life’’ the concept that transplantation tolerance is now feasible at least in some cases (1). This would benefit recipients by sparing them the toxicities of chronic immunosuppression and by potentially eliminating the need for retransplantation. He points out that young and highly sensitized patients although posing significant ethical and biological barriers to tolerance protocols, might be expected to benefit disproportionately.