Advances in Arrhythmia and Electrophysiology

Advances in cardiac ATP-sensitive K+ channelopathies from molecules to populations.

Is there a significant transmural gradient in repolarization time in the intact heart? Cellular basis of the T wave: a century of controversy.

The ECG is one of the oldest and most versatile noninvasive cardiac diagnostic tests. It has remained in use essentially in its original form despite dramatic advances in cardiac electrophysiology. In May 1887, Augustus Desiré Waller recorded the first human Electrogram using a primitive instrument called a Libbmann capillary electrometer. It had 2 deflections corresponding to ventricular depol...

Update on intensive care ECG and cardiac event monitoring.

This brief review is aimed primarily as a resource for the clinician and summarizes recent advancements in electrocardiographic monitoring in the intensive care unit. Emphasis is placed on recent advances in ICU ECG and cardiac event monitoring with particular attention to arrhythmia detection in patients following myocardial infarction. Specific topics addressed include: clinical indicators of...

Arrhythmia and Electrophysiology: the eagle can land.

In 2004, Joseph Loscalzo, the then-new editor-in-chief of Circulation, invited readers to use the journal to soar like an eagle above the cardiovascular landscape and to stay informed of cutting-edge advances in cardiovascular medicine. From that broad vista, readers could hone their focus to specific areas and monitor the latest findings that came to the fore in the highest-quality original in...

Status of Antiarrhythmic Drug Development for Atrial Fibrillation: New Drugs and New Molecular Mechanisms.

Atrial fibrillation (AF) is the most common cardiac arrhythmia, with a lifetime risk exceeding 20% by 80 years of age. AF is associated with a significant burden of morbidity and increased risk of mortality. Even with advances in catheter ablation procedures, antiarrhythmic drug therapy remains a cornerstone in the treatment of AF both to restore and maintain sinus rhythm. However, most are of ...

Protective effects of gallic acid on cardiac electrophysiology and arrhythmias during reperfusion in diabetes

Objective(s): Gallic acid (GA), a potent anti-oxidant, plays an important role in reducing diabetic induced cardiac disorders. Therefore, the present investigation was purposed to determine the beneficial effect of GA in cardiac arrhythmias during reperfusion in diabetes induced by alloxan. Materials and Methods: Male Sprague-Dawley rats...