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Reality-based User Interface System (RUIS)

We introduce Reality-based User Interface System (RUIS), a platform that even novice programmers can easily use for prototyping novel user interfaces. We implemented a puzzle application with a 3D user interface employing modified Nintendo Wii Remotes as 6-DOF controllers to showcase some of the features that are possible with our platform: two-handed gestural interaction, natural interaction m...

Noise and Signal Processing Extra syllabus for ( third - year ) course “ Signaalverwerking & Ruis ”

Rese Met

ownloade kground: Estimates of human papillomavirus (HPV) concordance among sexual partners are imporr various public health activities, from counseling individual patients to predicting the effect of HPV ation. thods:We systematically searched the PubMed and EMBASE databases for studies of HPV concordance heterosexual couples published through 2008 in English. Two coders independently abstract...

Targeting MET in Lung Cancer: Will Expectations Finally Be MET?

The hepatocyte growth factor receptor (MET) is a potential therapeutic target in a number of cancers, including NSCLC. In NSCLC, MET pathway activation is thought to occur through a diverse set of mechanisms that influence properties affecting cancer cell survival, growth, and invasiveness. Preclinical and clinical evidence suggests a role for MET activation as both a primary oncogenic driver i...

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

Inhibition of the mechanistic target of rapamycin (mTOR) is a promising treatment strategy for several cancer types. Rapamycin derivatives such as everolimus are allosteric mTOR inhibitors acting through interaction with the intracellular immunophilin FKBP12, a prolyl isomerase with different cellular functions. Although mTOR inhibitors have significantly improved survival of different cancer p...