منابع مشابه
Automated voltage-clamp technique.
The voltage-clamp electrophysiology method is the gold standard for measuring the function of ion channels. In the past, this technique has had limited applicability in pharmaceutical drug discovery because of its low throughput, steep learning curve, and challenges in standardization of the experiments. Recently, new electrophysiology platforms have been developed, which are based on the use o...
متن کاملVoltage clamp techniques
Much of what we know about the properties of ion channels in cell membranes has come from experiments using voltage clamp. In general, the method allows ion flow across a cell membrane to be measured as electric current, whilst the membrane voltage is held under experimental control with a feedback amplifier. The method was first developed by Cole (1949) and Hodgkin et al. (1952) for use with t...
متن کاملFrom overshoot to voltage clamp
when we were both living in Trinity College, Cambridge. He finished as an undergraduate in 1935 and was a research scholar and, from 1936, a Junior Research Fellow; I came up as an undergraduate in 1935. In the summer of 1939, he went to the marine laboratory at Plymouth to do experiments on the giant nerve fibres of squid. He invited me to join him, which I did at the beginning of August; we l...
متن کاملThe voltage clamp and cardiac electrophysiology.
• Although voltage clamp methods have been applied experimentally to cardiac tissue for over a decade, this field of study has failed to achieve general acceptance because of limitations of the experimental approach and difficulty in interpreting the results. Yet this technique is valuable within its limitations, and to dismiss it would be to lose a valuable tool. In perspective, most technique...
متن کاملThe resistance of the septum of the medium giant axon of the earthworm
It is generally thought that nexuses constitute low-resistance pathways between cell interiors in epithelial, neural, muscular, and even connective tissues. However, there are no reliable estimates of the specific resistance of a nexus. The reason for this is that in most cases the surfaces of nexuses between cells are geometrically complex and therefore it has been very hard to accurately esti...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1984
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(84)84143-0