Vascular dysfunction in adult mice generated by assisted reproductive technologies
نویسندگان
چکیده
منابع مشابه
Vascular Medicine Systemic and Pulmonary Vascular Dysfunction in Children Conceived by Assisted Reproductive Technologies
Background—Assisted reproductive technology (ART) involves the manipulation of early embryos at a time when they may be particularly vulnerable to external disturbances. Environmental influences during the embryonic and fetal development influence the individual’s susceptibility to cardiovascular disease, raising concerns about the potential consequences of ART on the long-term health of the of...
متن کاملPrevention of vascular dysfunction and arterial hypertension in mice generated by assisted reproductive technologies by addition of melatonin to culture media.
Assisted reproductive technologies (ART) induce vascular dysfunction in humans and mice. In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis. Melatonin is involved in epigenetic regulation, and its administration to sterile women improves ...
متن کاملCardiovascular dysfunction in children conceived by assisted reproductive technologies.
Epidemiological studies demonstrate a relationship between pathological events during foetal development and future cardiovascular risk and the term 'foetal programming of cardiovascular disease' has been coined to describe this phenomenon. The use of assisted reproductive technologies (ARTs) is growing exponentially and 2-5% of children are now born by this procedure. Emerging evidence indicat...
متن کاملSystemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies.
BACKGROUND Assisted reproductive technology (ART) involves the manipulation of early embryos at a time when they may be particularly vulnerable to external disturbances. Environmental influences during the embryonic and fetal development influence the individual's susceptibility to cardiovascular disease, raising concerns about the potential consequences of ART on the long-term health of the of...
متن کاملLetter by Phillips and O'Leary regarding article, "systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies".
I read with interest the article by Scherrer et al. This research was largely advertised in a Swiss television show, 36.9, on April 4, 2012. In this show, it was clearly evident that children conceived by assisted reproduction techniques were informed of the hypothesis of the study before the measurements, that they were at risk to be victims of heart infarction at a very young age, and that th...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.172.4