Validamycin G and validoxylamine G, new members of the validamycins.
نویسندگان
چکیده
منابع مشابه
Microbial transformation of validamycins.
Alpha- or beta-Glucosidic linkage of validamycin was selectively cleaved by microbial hydrolysis and especially the conversion of validamycin C into validamycin A by the selective hydrolysis of alpha-glucoside linkage has important significance because validamycin C is considerably less active than validamycin A. Semisyntheses of validamycins including a new validamycin, beta-D-galactosyl-vali...
متن کاملEffect of validamycins on glycohydrolases of Rhizoctonia solani.
The pseudo-oligosaccharides, validamycins, showed potent inhibitory activity against trehalase of Rhizoctonia solani while no significant inhibition was exhibited against cellulase, pectinase, chitinase, alpha-amylase, alpha- and beta-glucosidases. In particular, validoxylamine A strongly inhibited trehalase in a competitive manner with a Ki value of 1.9 X 10(-9) M. The uptake of the antibiotic...
متن کاملOn a new G-frame and duality
We introduce a new g-frame (singleton g-frame), g-orthonormal basis and g-Riesz basis and study corresponding notions in some other generalizations of frames.Also, we investigate duality for some kinds of g-frames. Finally, we illustrate an example which provides a suitable translation from discrete frames to Sun's g-frames.
متن کاملFunctional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.
A 45 kb DNA sequencing analysis from Streptomyces hygroscopicus 5008 involved in validamycin A (VAL-A) biosynthesis revealed 16 structural genes, 2 regulatory genes, 5 genes related transport, transposition/integration or tellurium resistance; another 4 genes had no obvious identity. The VAL-A biosynthetic pathway was proposed, with assignment of the required genetic functions confined to the s...
متن کاملBiosynthetic studies on validamycins. I. 1H and 13C NMR assignments of validamycin A.
The 1H and 13C NMR spectra of validamycin A have been assigned by use of 2D homonuclear correlation spectroscopy for protons, and off-resonance decoupling, single frequency off-resonance decoupling, and comparison studies with model compounds for carbons. Effects of pH on carbon chemical shifts have also been studied.
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1986
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.39.1491