Use of G-methods for handling time-varying confounding in observational research

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Handling time varying confounding in observational research.

Many exposures of epidemiological interest are time varying, and the values of potential confounders may change over time leading to time varying confounding. The aim of many longitudinal studies is to estimate the causal effect of a time varying exposure on an outcome that requires adjusting for time varying confounding. Time varying confounding affected by previous exposure often occurs in pr...

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Adjusting for Time-Varying Confounding in Survival Analysis

Adjusting for Time-Varying Confounding in Survival Analysis In this paper we illustrate how directly including endogenous time-varying confounders in the model of the effect of an exposure on a response can lead to bias in discrete time survival analysis. An alternative to this method is Hernán, Brumback and Robins’ (1999) use of sample weights to adjust for endogenous time-varying confounding....

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ژورنال

عنوان ژورنال: The Lancet Global Health

سال: 2019

ISSN: 2214-109X

DOI: 10.1016/s2214-109x(18)30471-6