Use of Cyclosporine in Uterine Transplantation
نویسندگان
چکیده
منابع مشابه
Use of Cyclosporine in Uterine Transplantation
Uterine transplantation has been proposed as a possible solution to absolute uterine factor infertility untreatable by any other option. Since the first human attempt in 2000, various teams have tried to clarify which immunosuppressant would be most suitable for protecting the allogeneic uterine graft while posing a minimal risk to the fetus. Cyclosporine A (CsA) is an immunosuppressant widely ...
متن کاملLaboratory Monitoring of Cyclosporine Pre-dose Concentration (C0) After Kidney Transplantation in Isfahan
Background: Cyclosporine is the main immunosuppressive agent used in organ transplantation which leads to considerable improvement in graft survival. The large inter- and intra- patient variability in cyclosporine pharmacokinetics coupled with the agent’s narrow therapeutic index and adverse effects necessitate therapeutic monitoring of cyclosporine blood levels. Objective: The aim of this stu...
متن کاملThe significance of determining the therapeutic dose of cyclosporine-A in patients undergoing organ transplantation
Immunosuppressive drugs are now unavoidibly used after the transpantation of liver,heart and bone marrow, as well as in certain autoimmune diseases.among these agents,cyclosporine-A (CYA) is one of the most effective Immunosuppressants which is widely used.but as any Immunosuppressive agent,the use of CYA is not without harmful side effects.neurotoxin,nephrotoxic and hepatotoxic complications,m...
متن کاملNephrotoxicity of cyclosporine in liver transplantation.
SINCE the introduction of cyclosporine (CsA)-steroid therapy for our liver transplant recipients in March 1980, the survival rates have increased significantly as shown in Fig 1. The effective and relatively safe immunosuppression provided by CsA is undoubtedly the most important factor in the improved success rate. l N~'phrotoxicity is a troublesome side effect of CsA. The distinction between ...
متن کاملIMMUNOSUPPRESSION BEFORE CYCLOSPORINE Renal Transplantation
The concept of liver transplantation is a relatively recent one. The first descriptions of liver replacement in experimental animals were published less than 25 years ago,I,2 and the first attempt at clinical liver transplantation was not made until March I, 1963.3 The pace of clinical trials remained limited until 1980, the year when the new immunosuppressive agent cyclosporine was introduced....
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ژورنال
عنوان ژورنال: Journal of Transplantation
سال: 2012
ISSN: 2090-0007,2090-0015
DOI: 10.1155/2012/134936