Update on Cyclooxygenase-2 Inhibitors

Update on cyclooxygenase-2 inhibitors.

Nonsteroidal anti-inflammatory drugs represent the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Cyclooxygenase-2 (COX-2) inhibitors were initially touted as a therapeutic strategy to avoid not only the gastrointestinal but also the renal and cardiovascular side effects of nonspecific nonsteroidal anti-in...

Synthesis and Effects of 4,5-Diaryl-2-(2-alkylthio-5-imidazolyl) Imidazoles as Selective Cyclooxygenase Inhibitors

Objective(s) In recent years highly selective COX-2inhibitors were withdrawn from the market because of an increased risk of cardiovascular complications. In this study we were looking for potent compounds with moderate selectivity for cox-2. So, four analogues of 4, 5-diaryl-2-(2-alkylthio-5-imidazolyl) imidazole derivatives were synthesized and their anti-inflammatory and anti-nociceptive ac...

Cyclooxygenase-2 inhibitors in aspirin-sensitive asthma.

Cyclooxygenase-2 inhibitors: promise or peril?

The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized through inhibition of COX-2, while minimizing their adverse side effect profile associated with inhibition of COX-1. While COX-2 specific inhibitor...

Effects of Cyclooxygenase-2 Inhibitors on Fracture Healing

Introduction: Non-steroidal anti-inflammatory drugs (NSAID) are among the most widely prescribed drugs worldwide. However, there have been theoretical concerns about the effect of NSAIDs on bone metabolism and healing. These concerns have resurfaced with the recent discover of the Cyclooxygenase-2 (COX-2) isoform which is involved in inflammation and the development of COX-2 specific drugs. The...