Unlocking the DEAD-box: a key to cryptococcal virulence?
نویسندگان
چکیده
منابع مشابه
Unlocking the Mysteries of the Bounding Box
Few geospatial data representations are more basic than the bounding box; a rectangle surrounding a geographic feature or dataset. Bounding boxes are a key component of geospatial metadata and lie at the heart of many computational geometry algorithms as well as spatial indexing systems. Despite their ubiquity and common use, bounding boxes are more complicated than they first appear. The phras...
متن کاملThe Molecular Apgar Score: A Key to Unlocking Evolutionary Principles
One of the first "tools" used for systematically evaluating successful newborn transitional physiology at birth was the Apgar Score, devised by Virginia Apgar in 1953. This objective assessment tool allowed clinicians to immediately gauge the relative success of a newborn infant making the transition from the in utero liquid immersive environment to the ex utero gas environment in the delivery ...
متن کاملCryptococcal virulence: beyond the usual suspects.
In this issue of the JCI, the observation of the altered pathogenicity of a Cryptococcus neoformans glucosylceramide (GlcCer) mutant shines new light on the initiation of cryptococcal infection. Rittershaus and colleagues demonstrate that the cell surface glycosphingolipid GlcCer is essential for the fungus to grow in the extracellular environments of the host bloodstream and alveolar spaces of...
متن کاملComputational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response.
UNLABELLED Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills over 600,000 people annually. Here, we report integrated computational and experimental investigations of the role and mechanisms of transcriptional regulation in cryptococcal infection. Major cryptococcal virulence traits include melanin production and the development of a large polysaccharide capsule ...
متن کاملDEAD-box proteins
How are they identified? Originally, these proteins were identified by genetic approaches. Comparison of their amino acid sequences revealed a high degree of conservation of eight different motifs. They are present in a core region that is flanked by 5′ and 3′ external sequences of various length. The systematic sequencing of genomes, reverse genetics and genetic methods have revealed the wides...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2005
ISSN: 0021-9738
DOI: 10.1172/jci200524508