Type 6 Secretion System-Mediated Immunity to Type 4 Secretion System-Mediated Gene Transfer
نویسندگان
چکیده
منابع مشابه
Type III secretion system
The type III secretion system (T3SS) is a membrane-embedded nanomachine found in several Gram-negative bacteria. Upon contact between bacteria and host cells, the syringe-like T3SS (Figure 1) transfers proteins termed effectors from the bacterial cytosol to the cytoplasm or the plasma membrane of a single target cell. This is a major difference from secretion systems that merely release molecul...
متن کاملType VI secretion system
Bacteria employ a variety of tools to survive in a competitive environment. Salomon and Orth describe one such tool-the Type 6 Secretion Systems used by bacteria to deliver a variety of toxins into competing cells.
متن کاملType VI secretion system: secretion by a contractile nanomachine
The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative bacteria. Several key components of T6SS are evolutionarily related to components of contractile nanomachines such as phages and R-type pyocins. The T6SS assembly is initiated by formation of a membrane complex that binds a phage-like baseplate with a sharp spike, and this is followed by polymerization of a...
متن کاملMarker for type VI secretion system effectors.
Bacteria use diverse mechanisms to kill, manipulate, and compete with other cells. The recently discovered type VI secretion system (T6SS) is widespread in bacterial pathogens and used to deliver virulence effector proteins into target cells. Using comparative proteomics, we identified two previously unidentified T6SS effectors that contained a conserved motif. Bioinformatic analyses revealed t...
متن کاملAssembly of the type II secretion system.
The type II secretion system is utilized by many Gram-negative bacteria to export folded proteins to the surface and/or the extracellular environment of the cell. Although the function of the system is to move proteins from the periplasm to the outside of the cell, it is a large trans-envelope structure composed of more than a dozen different proteins present in multiple copies, including perip...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1243745