Two pericentric inversions of human chromosome 11.

Two pericentric inversions of human chromosome 11.

A pericentric inv(11) (pl5q23) detectable by G-, Q-, and R-banding and occuring in 1 member of each of 3 generations of a family is described. In another family studied by several banding methods in search of chromosomal markers, a pericentric inv(11) (p11q11) was found. It was detectable only by C-banding, the darkly staining band being located on the short-arm side of the centromere. The reas...

High resolution of a small pericentric inversion of chromosome 11.

A pericentric inversion 11 (p11q13.3) segragating in two generations is described. A high degree of resolution of the inversion was achieved by using prophase and prometaphase chromosomes from methotrexate-synchronised cells. The inversion occurred in a mother and three of her ten children. It had no detectable clinical consequences.

Familial pericentric inversion of chromosome 11 detected prenatally.

Preimplantation genetic diagnosis of pericentric inversions.

Inversions are structural chromosome abnormalities that may be associated with infertility, multiple miscarriage and chromosomally unbalanced offspring. Preimplantation genetic diagnosis (PGD) with subtelomeric probes was used to select for transfer only those embryos that were normal or balanced for three pericentric inversions. In contrast to previous protocols the present procedure allows th...

Pericentric inversion of chromosome 11 in one of two similar retarded brothers.

We report two brothers, aged 2k and 4i, with similar features, namely developmental delay, short stature, and small delicate facies. Chromosome analysis revealed a pericentric inversion of chromosome 11 in one boy and a normal karyotype in the other. The father was shown to be the carrier of this pericentric inversion. Two brothers with mental retardation, particularly in the area of speech dev...