Tuning Brain Blood Flow

5 Brain metabolism and cerebral blood flow

Cerebral blood flow is influenced and regulated by a number of factors, including arterial blood pressure, intracranial pressure, venous outflow, blood viscosity, PaCO2 and PaO2, collateral flow, vasoreactivity and the status of cerebral autoregulation. The regulation of vascular resistance lies mainly in the arterioles and precapillary segments (Auer and Loew, 1983). It is important to note th...

The system approach to brain blood flow.

The clinical approach to ischemia of the brain is burdened by practices established by custom and by conflicting terminologies and perspectives tailored to the individual needs of diverse medical specialties. There is a need for a common terminology resting on basic definitions and concepts that precisely reflect anatomical, physiological, and pathological states. The integration of multiple di...

Usefulness of brain blood-flow imaging.

Abnormal cerebral blood flow in methamphetamine abusers assessed by brain perfusion single emission computed tomography

Introduction:Amphetamines are central nervous system (CNS) stimulant substances and amphetamine abuse is considered a growing problem in our country. Previous studies revealed destructive effects of amphetamines on metabolism, perfusion and structure of brain. The aim of current study was evaluating regional cerebral blood flow (rCBF) disturbances in methamphetamine (MA) abuser...

Detecting tissue deterioration after brain injury: regional blood flow level versus capacity to raise blood flow

Regional cerebral blood flow (rCBF) is spatially and temporally adjusted to local energy needs. This coupling involves dilation of vessels both at the site of metabolite exchange and upstream of the activated region. Deficits in upstream blood supply limit the 'capacity to raise rCBF' in response to functional activation and therefore compromise brain function. We here demonstrate in rats that ...