Tumor microenvironment-responsive metal nanotherapeutics for breast cancer chemo-/immunotherapy

Abstract Many metal complexes not only had excellent cytotoxic antitumor effects but also could function as a positive immunomodulatory to improve by modifying the local tumor microenvironment. Herein, dual-target nanotherapeutics (MP3/ACPP/AE105@NPs) with uPAR targeting and microenvironment-responsive ability was developed using AE105 ligand ACPP peptide locate complex cells. Assisted surface modification, MP3/ACPP/AE105@NPs demonstrated cellular uptake of drugs in vitro experiments, thereby enhancing therapeutic utility loaded complex. The induced excessive ROS generation inhibiting activity TrxR modulated those proteins which were related metastasis through ERK/AKT activation mediated FAK MDA-MB-231 This significantly benefits vivo accompanied reduced toxic side effects. Importantly, treatment stimulated immunotherapeutic response, indicated tumor-infiltrated T cells, improved maturation dendritic cells (DCs), proliferation-inhibitory effect tumor-associated M2 macrophages. Taken together, results suggested that this dual-targeted offered new opportunities for boosting synergistic breast cancer chemotherapy immunotherapy.