منابع مشابه
Modeling the Relationship between Fluorodeoxyglucose Uptake and Tumor Radioresistance as a Function of the Tumor Microenvironment
High fluorodeoxyglucose positron emission tomography (FDG-PET) uptake in tumors has often been correlated with increasing local failure and shorter overall survival, but the radiobiological mechanisms of this uptake are unclear. We explore the relationship between FDG-PET uptake and tumor radioresistance using a mechanistic model that considers cellular status as a function of microenvironmenta...
متن کاملMolecular Biology of Tumor Radioresistance
Surgery, radiation and chemotherapy are the major therapeutic options for treatment of human malignancies. In particular, more than 50% of newly diagnosed cancer patients worldwide receive radiotherapy (alone or in combination with chemotherapy or surgery) at some point during their treatment (Nygren et al., 2001). However, the curative potential of radiotherapy is often limited by intrinsic ra...
متن کاملTumor Microenvironment
Abstract While genetic changes are critical for the malignant transformation of epithelial cells, the microenvironment in which the cells reside also governs carcinogenesis. Most tumors arise within a cellular microenvironment characterized by suppressed host immunity, dysregulated inflammation, and increased production of cellular growth and survival factors that induce angiogenesis and inhibi...
متن کاملTumor Microenvironment and Metabolism
The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...].
متن کاملTumor microenvironment and angiogenesis.
The tumor microenvironment is a mixture of extracellular matrix molecules, tumor cells, endothelial cells, fibroblasts and immune cells. Tumor growth and metastasis formation are dependent on the growth of blood vessels into the tumor mass. The tumor microenvironment contributes to this pathological angiogenic process. The extracellular matrix and basement membranes are a source for endogenous ...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2021
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-021-00640-9