Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK
نویسندگان
چکیده
منابع مشابه
Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK
MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose expression is upregulated in many cancers. MAGE-A3 and -A6 act as oncogenes and recent work now shows that they degrade the central metabolic regulator AMPK, providing a novel mechanism for rewiring cancer metabolism.
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ژورنال
عنوان ژورنال: Current Biology
سال: 2015
ISSN: 0960-9822
DOI: 10.1016/j.cub.2015.03.019