TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity
نویسندگان
چکیده
منابع مشابه
Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits
The nonselective cation channel transient receptor potential ankyrin 1 (TRPA1) is known to be a key contributor to both somatosensation and pain. Recent studies have implicated TRPA1 in additional physiologic functions and have also suggested that TRPA1 is expressed in nonneuronal tissues. Thus, it has become necessary to resolve the importance of TRPA1 expressed in primary sensory neurons, par...
متن کاملTRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity
BACKGROUND Mechanisms underlying postoperative pain remain poorly understood. In rodents, skin-only incisions induce mechanical and heat hypersensitivity similar to levels observed with skin plus deep incisions. Therefore, cutaneous injury might drive the majority of postoperative pain. TRPA1 and TRPV1 channels are known to mediate inflammatory and nerve injury pain, making them key targets for...
متن کاملTRPA1 Mediates Mechanical Currents in the Plasma Membrane of Mouse Sensory Neurons
Mechanosensitive channels serve as essential sensors for cells to interact with their environment. The identity of mechanosensitive channels that underlie somatosensory touch transduction is still a mystery. One promising mechanotransduction candidate is the Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel. To determine the role of TRPA1 in the generation of mechanically-sensitive cur...
متن کاملPeripheral and spinal TRPA1 channels contribute to formalin-induced long-lasting mechanical hypersensitivity
Background Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has been less studied. The purpose of this study was to investigate the local periph...
متن کاملTRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury.
Cold hyperalgesia is a well-documented symptom of inflammatory and neuropathic pain; however, the underlying mechanisms of this enhanced sensitivity to cold are poorly understood. A subset of transient receptor potential (TRP) channels mediates thermosensation and is expressed in sensory tissues, such as nociceptors and skin. Here we report that the pharmacological blockade of TRPA1 in primary ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2011
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2011.206789