Treatment of Osteoporosis with Parathyroid Hormone and Teriparatide
نویسندگان
چکیده
منابع مشابه
Teriparatide (recombinant human parathyroid hormone 1-34) in postmenopausal women with osteoporosis: systematic review.
CONTEXT AND OBJECTIVE Osteoporosis is defined as a disease characterized by low bone mass and deterioration of the bone tissue microarchitecture. Teriparatide stimulates the formation and action of osteoblasts, which are responsible for bone formation, thus promoting bone tissue increase. The aim was to assess the effectiveness and safety of teriparatide for treating postmenopausal osteoporosis...
متن کاملParathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use.
All therapies currently recommended for the management of osteoporosis act mainly to inhibit bone resorption and reduce bone remodeling. PTH and its analog, teriparatide [recombinant human PTH(1-34)], represent a new class of anabolic therapies for the treatment of severe osteoporosis, having the potential to improve skeletal microarchitecture. Significant reductions in both vertebral and appen...
متن کاملSafety of parathyroid hormone for the treatment of osteoporosis.
Teriparatide (recombinant human 1-34 parathyroid hormone) has been registered for the treatment of postmenopausal osteoporosis and osteoporosis in men for more than 5 years, whereas 1-84 parathyroid hormone has just recently been registered in Europe for osteoporosis management. Therefore, more data are available regarding the long-term safety of teriparatide. The issues to be considered are th...
متن کاملParathyroid hormone for the treatment of osteoporosis: a systematic review.
BACKGROUND Human parathyroid hormone (hPTH)(1-34) was approved in 2004 for the treatment of severe osteoporosis. Members of the Osteoporosis Canada clinical guidelines committee conducted a systematic review of randomized controlled trials (RCTs) to assess the efficacy and safety of hPTH for fracture prevention in postmenopausal women and men with osteoporosis. METHODS We searched MEDLINE, EM...
متن کاملTreatment of osteoporosis with Teriparatide rhPTH(1-34).
Currently, treatment with parathyroid hormone (PTH) is the only proven and approved method of increasing bone mass and improving bone architecture. This section reviews some selected aspects of treatment with Teriparatide rhPTH(1-34). Teriparatide stimulates bone formation and remodeling thereby increasing BMD as measured by DXA and improves micro architecture (such as BV/TV, trabecular thickne...
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ژورنال
عنوان ژورنال: Calcified Tissue International
سال: 2009
ISSN: 0171-967X,1432-0827
DOI: 10.1007/s00223-009-9291-1