Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

Active During Allograft Tolerance Tracking the Immunoregulatory Mechanisms

Mechanisms of Maternal Immune Tolerance During Pregnancy

Throughout their evolution, animals have developed mechanisms which protect them against parasites or infections by detecting and destroying foreign biological material within their own bodies. These mechanisms for excluding “non-self” biological materials whilst at the same time maintaining the integrity of the “self” have evolved for hundreds of millions of years into a highly complex body sy...

Multiple mechanisms of peripheral T cell tolerance to the fetal "allograft".

The fetus represents a foreign entity to the maternal immune system, yet this "natural" allograft is not normally rejected. This unique situation provides a physiologic system to evaluate peripheral tolerance in which the maternal immune system is challenged with relatively rare Ags not previously encountered in the thymus. Using H-Y-specific TCR transgenic mice, we demonstrate that T cells spe...

Cutting Edge: Multiple Mechanisms of Peripheral T Cell Tolerance to the Fetal “Allograft”

Oral tolerance, an active immunologic process mediated by multiple mechanisms.

Oral tolerance, the specific suppression of cellular and/or humoral immune responses to an antigen by prior administration of the antigen by the oral route, probably evolved to prevent hypersensitivity reactions to food proteins and bacterial antigens present in the mucosal flora. As with other forms of immunologic tolerance, oral tolerance also provides mechanisms to suppress pathologic reacti...