TP53 Abnormalities and Genetic Instability in Breast Cancer

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TP53 and breast cancer.

The TP53 gene (p53) is found altered in breast carcinomas in approximately 20-40% of all cases depending on tumor size and stage of the disease. It seems to be an early event in breast tumorigenesis. Several polymorphisms in the TP53 gene have been detected and their possible roles in breast cancer risk and association to type of cancer developed are discussed. The different mutation spectra se...

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ژورنال

عنوان ژورنال: Acta Oncologica

سال: 1995

ISSN: 0284-186X,1651-226X

DOI: 10.3109/02841869509094045