Toxicity of anthelmintic drugs (fenbendazole and flubendazole) to aquatic organisms

Toxicity of anthelmintic drugs (fenbendazole and flubendazole) to aquatic organisms

Flubendazole (FLU) and fenbendazole (FEN) belong to benzimidazoles-pharmaceuticals widely used in veterinary and human medicine for the treatment of intestinal parasites as well as for the treatment of systemic worm infections. In recent years, usage of these drugs increased, which resulted in a larger contamination of the environment and possible negative effects on biota. Hence, in our resear...

Toxicity of fluoroquinolone antibiotics to aquatic organisms.

Toxicity tests were performed with seven fluoroquinolone antibiotics, ciprofloxacin, lomefloxacin, ofloxacin, levofloxacin, clinafloxacin, enrofloxacin, and flumequine, on five aquatic organisms. Overall toxicity values ranged from 7.9 to 23,000 microg/L. The cyanobacterium Microcystis aeruginosa was the most sensitive organism (5-d growth and reproduction, effective concentrations [EC50s] rang...

Agricultural pesticide toxicity to aquatic organisms - a literature review

Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.

Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths. The microtubule-disrupting prop...

Guanicid and Phmg Toxicity Tests on Aquatic Organisms

POŠTULKOVÁ EVA, KOPP RADOVAN. 2016. Guanicid and PHMG Toxicity Tests on Aquatic Organisms. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 64(1): 129–134. The emergence and development of new algicidal products is caused by the ever increasing popularity of garden ponds as well as the use of these products in the fi sheries sector, especially for disposal of cyanobacteri...