منابع مشابه
Total synthesis of dl-19-nor-16,17-dehydroprogesterone.
dl-2-(7,11-Dimethyl-3,7,11 - trans,trans-dodecatrienyl)-3-methyl-cyclopent-2-enol was prepared by reduction of the corresponding ketone. This tetraenol, on treatment with trifluoroacetic acid, underwent stereoselective cyclization to give dl-3,17-dimethyl-A-nor-D-homoestra-3,16-diene. This tetracyclic material was readily converted, by oxidative cleavage to the bicyclic triketo aldehyde followe...
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DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl[2-14C] acetate as part of a 6-step sequence.
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rearrangement were elucidated and we assumed that a total synthesis of 1would be a straightforwardmatter. As described below, we were indeed able to accomplish the inaugural total synthesis of phalarine using the rearrangement strategy, although significant obstacles had to be overcome. For a total synthesis of phalarine, it would be best if the rearrangement could be conducted on an advanced-s...
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Due to their architectural intricacy and biological significance, the synthesis of polycyclic diterpenes and their biogenetically related alkaloids have been the subject of considerable interest over the last few decades, with progress including the impressive synthesis of several elusive targets. Despite tremendous efforts, conquering the unique structural types of this large natural product f...
متن کاملTotal synthesis of (-)-acutumine.
The first total synthesis of the tetracyclic alkaloid (-)-acutumine is described. Key reactions include an asymmetric ketone allylation mediated by Nakamura's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, and the Lewis acid-promoted cyclization of an amine onto an alpha,beta-unsaturated dimethyl ketal.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1970
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.18.416