منابع مشابه
Yin yang
oxidative Medicine and celluar Longevity 227 Derived from classical Chinese philosophy and with frequent applications in Chinese medicine, " yin yang " has grown into an interesting concept that may have a number of applications. The term is usually used to depict the existence of polarizing or opposing forces in nature. Yet, the concept of " yin yang " can be much more involved, especially in ...
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In this issue of Blood, Boulaftali and colleagues have made the important and novel observation that deficiency of the serine protease inhibitor (serpin), PN-1, in platelets results in a prothrombotic state, supporting the role of platelet PN-1 in thrombosis.1 Specifically, Boulaftali et al have initially confirmed previously published studies by Gronke et al indicating that protease nexin-1 (P...
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The study of protein aggregation saw a renaissance in the last decade, when it was discovered that aggregation is the cause of several human diseases, making this field of research one of the most exciting frontiers in science today. Building on knowledge about protein folding energy landscapes, determined using an array of biophysical methods, theory and simulation, new light is now being shed...
متن کاملThe Yin and Yang of arterial inflammation.
he recent wave of enthusiasm for including inflammation s one of the primary pathophysiologic processes in cardioascular disease has substantial merit (1). Arterial inflamation is central to plaque progression and plaque rupture. mong clinical markers of inflammation, C-reactive protein CRP), a complex pentameric protein largely of hepatic rigin, is the current gold standard (2,3). In a variety...
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Microglia, the resident immune cells of the mammalian central nervous system (CNS), play a pivotal role in both physiological and pathological conditions such as the restoration of CNS integrity and the progression of neurodegenerative disorders. Extensive data have been published that describe neuroinflammation by microglial activation to have detrimental consequences on the developing and mat...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2016
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddw207