The Relative Osmotic Resistance of Chronic Lymphocytic Leukemia Lymphocytes
نویسندگان
چکیده
منابع مشابه
The relative osmotic resistance of chronic lymphocytic leukemia lymphocytes.
By DAVID \V. \\ESTRING AND SUZANNE B. BnrrrlN T lIE HEMOLYTIC RESPONSE of erythrocytes to hypotonic stress is well known. Complex enzyme systems are required by the cell to maintam membrane integrity during exposure to hypotonic solutions. When certain of these enzymes are defective, erythrocyte osmotic fragility may be altered.3 On the other hand, the response of leukocytes to osmotic stress h...
متن کاملAnalysis of HLA-G Gene Expression in B-Lymphocytes from Chronic Lymphocytic Leukemia Patients
The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA...
متن کاملThe role of microRNA in acute/chronic, myeloid/lymphocytic leukemia
MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...
متن کاملBeyond Ibrutinib Resistance in Chronic Lymphocytic Leukemia
Despite ibrutinib activity in multiple B-cell malignancies, cases of primary and secondary resistance have emerged. The overall reported frequency of resistance is low. Resistance has been found to be caused by a mutation in the BTK binding site of ibrutinib or gain-of-function mutations in PLCG2, which lead to autonomous BCR activity. Improved understanding of mechanisms of primary and seconda...
متن کاملIbrutinib resistance in chronic lymphocytic leukemia.
n engl j med 370;24 nejm.org june 12, 2014 2352 portant questions both about the nature of the evidence and about its sufficiency, a topic that has been the subject of inquiry and discussion in the patient-safety community for well over a decade.1 As noted in the editorial, replications have confirmed substantial effects regarding the use of a surgical checklist, but rigorous randomized trials ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1967
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v30.5.674.674