The original sin of Cockcroft-Gault formula

Should we continue to use the Cockcroft-Gault formula?

BACKGROUND/AIMS Although the National Kidney Disease Education Program recommends use of the modification of diet in renal disease (MDRD) formula to estimate the glomerular filtration rate (GFR), most drug-dosing recommendations and clinical practices employ the Cockcroft-Gault (CG) formula. The quality score of the original MDRD study was better than that of the original CG study, although the...

Should We Continue to Use the Cockcroft-Gault Formula?

Background/Aims: Although the National Kidney Disease Education Program recommends use of the modification of diet in renal disease (MDRD) formula to estimate the glomerular filtration rate (GFR), most drug-dosing recommendations and clinical practices employ the Cockcroft-Gault (CG) formula. The quality score of the original MDRD study was better than that of the original CG study, although th...

Effect of creatinine assay standardization on the performance of Cockcroft-Gault and MDRD formula in predicting GFR.

CAPD patients given lercanidipine developed non-infective turbid peritoneal dialysis. Differential diagnosis of non-infectious cloudy peritoneal dialysate includes cellular causes (i.e. leucocyte, eosinophils, red cells and malign cells) and non-cellular causes (i.e. triglyceride and drugs) [2]. Yoshimoto et al. [1,3] reported that benidipine, manidipine, nisoldipine and nifedipine caused cloud...

Genetics of Original Sin

The continuous repetition of Christian de Duve’s primary thesis in Genetics of Original Sin ensures that however little the reader understands or is interested in biology, he will have no doubt as to the author’s primary concern: Natural selection has made humans poor prognosticators. As evolutionary adaptation is all about living (and reproducing) in the moment, humans have evolved some unfort...

Original sin and education.