The Impairment of ILK Related Angiogenesis Involved in Cardiac Maladaptation after Infarction
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چکیده
منابع مشابه
The Impairment of ILK Related Angiogenesis Involved in Cardiac Maladaptation after Infarction
BACKGROUND Integrin linked kinase (ILK), as an important component of mechanical stretch sensor, can initiate cellular signaling response in the heart when cardiac preload increases. Previous work demonstrated increased ILK expression could induce angiogenesis to improved heart function after MI. However the patholo-physiological role of ILK in cardiac remodeling after MI is not clear. METHOD...
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BACKGROUND Gender can influence post-infarction cardiac remodeling. OBJECTIVE To evaluate whether gender influences left ventricular (LV) remodeling and integrin-linked kinase (ILK) after myocardial infarction (MI). METHODS Female and male Wistar rats were assigned to one of three groups: sham, moderate MI (size: 20-39% of LV area), and large MI (size: ≥40% of LV area). MI was induced by co...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0024115