The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3′UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2

Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2.

The gene encoding the architectural transcription factor HMGA2 is frequently rearranged in several benign tumors of mesenchymal origin. The lipoma preferred partner (LPP) gene is the most frequent translocation partner of HMGA2 in a subgroup of lipomas, which are benign tumors of adipose tissue. In these lipomas, HMGA2/LPP fusion transcripts are expressed, which encode for the three AT-hooks of...

Oncogenic HMGA2: short or small?

The High Mobility Group A (HMGA) family of proteins are architectural transcription factors that bind to DNA and introduce structural alterations in chromatin. The HMGA family consists of two members, HMGA1 and HMGA2, which are encoded by separate genes. As one of the major nonhistone chromosomal proteins, HMGA proteins are multifunctional and are involved in many fundamental cellular processes...

Hematopoietic Clonal Expansion in Mpn by Hmga2

Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by clonal proliferative hematopoiesis with increased blood cell count. Clonal expansion mechanisms in MPN and related disorders such as myelodysplastic syndromes (MDS) remain to be elucidated. Although mutations in the JAK2...

بررسی ارتباط پلی مورفیسم rs10573247 در 3UTR ژن HMGA2 با خطر ابتلا به سرطان معده

HMGA2 is a driver of tumor metastasis.

The non-histone chromatin-binding protein HMGA2 is expressed predominantly in the mesenchyme before its differentiation, but it is also expressed in tumors of epithelial origin. Ectopic expression of HMGA2 in epithelial cells induces epithelial-mesenchymal transition (EMT), which has been implicated in the acquisition of metastatic characters in tumor cells. However, little is known about in vi...