The emerging genetic landscape underlying cardiac conduction system function
نویسندگان
چکیده
منابع مشابه
Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System
Vertebrate hearts depend on highly specialized cardiomyocytes that form the cardiac conduction system (CCS) to coordinate chamber contraction and drive blood efficiently and unidirectionally throughout the organism. Defects in this specialized wiring system can lead to syncope and sudden cardiac death. Thus, a greater understanding of cardiac conduction development may help to prevent these dev...
متن کاملGenetic wiring diagram of the cardiac conduction system.
In 1906, Tawara published his treatise, recently translated from German to English,1 on the anatomy of the cardiac conduction system, which he elucidated through painstaking dissection and histological examination. In the following decades, the conduction system was generally understood and studied in anatomic and physiological terms. Most molecular biology focused on the genes and proteins tha...
متن کاملTBX5 drives Scn5a expression to regulate cardiac conduction system function.
Cardiac conduction system (CCS) disease, which results in disrupted conduction and impaired cardiac rhythm, is common with significant morbidity and mortality. Current treatment options are limited, and rational efforts to develop cell-based and regenerative therapies require knowledge of the molecular networks that establish and maintain CCS function. Recent genome-wide association studies (GW...
متن کاملConduction System in Cardiac Rejection
Correlation of electrocardiographic abnormalities occurring postoperatively with lesions of the conduction system found at autopsy was done in 20 dogs which had received cardiac homografts. The incidence of arrhythmias closely paralleled the severity of rejection injury found within the heart and specifically within the conduction system. Severe pathological changes in the conduction system (gr...
متن کاملLineages of the Cardiac Conduction System
The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties. A better understanding of the origin and specification of CCS lineages has allowed us to better comprehend the etiology of CCS disease and has provided leads for development of therapies. A variet...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2011
ISSN: 1542-0752
DOI: 10.1002/bdra.20800