The Clinical Value of Autoantibodies in Rheumatoid Arthritis
نویسندگان
چکیده
منابع مشابه
Autoantibodies in normals – the value of predicting rheumatoid arthritis
Introduction The cause of rheumatoid arthritis (RA) remains elusive, however, a study demonstrating synovitis in clinically uninflamed joints [1] and several studies reporting the presence of characteristic autoantibodies (IgM rheumatoid factor [RF] and anti-cyclic citrullinated peptide [CCP] antibodies) prior to the appearance of disease manifestations [2–7] have provided evidence of a preclin...
متن کاملAutoantibodies in rheumatoid arthritis
(e--mail: [email protected]) Although the incidence and prevalence of individual autoimmune diseases are not high (table), the population burden of the disease is large and underestimated. Serum autoantibodies, which appear long before onset of clinical disease, are a characteristic feature, as recently emphasised by Markus Nielen and colleagues. Studying patients with rheumatoid arth...
متن کاملThe Spectrum and Clinical Significance of Autoantibodies in Rheumatoid Arthritis
In the late 19th century, early 20th, the main known rheumatic diseases were Gout, deforming arthritis (osteoarthritis), acute rheumatism (rheumatic fever), and chronic rheumatism [rheumatoid arthritis (RA)]. There was uncertainty whether acute and chronic rheumatisms were separate diseases or a single entity with heterogeneous manifestations according to the influence of age, heredity, and env...
متن کاملAutoantibodies in rheumatoid arthritis and their clinical significance
Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. However, a highly specific marker autoantibody for rheumatoid arthritis (RA) has not yet been determined. The presence of rheumatoid factors is currently used as a marker for RA. However, rheumatoid factors have modest specificity (~70%) for the disease. In recent years, several ...
متن کاملTherapeutic implications of autoantibodies in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by the presence of autoantibodies. Their value for diagnostic/prognostic purposes has been well established. In contrast, their role in established disease and their associations with disease activity is less clear. Moreover, as evidence is accumulating that these autoantibodies are causally involved in certain key aspects...
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ژورنال
عنوان ژورنال: Frontiers in Medicine
سال: 2018
ISSN: 2296-858X
DOI: 10.3389/fmed.2018.00339